Understanding the Differences Between Colorectal Cancer Screening Methods

You know what you can do for those you love? Get screened!

Colorectal cancer is one of the most preventable cancers, thanks to effective screening tools that detect cancer early—or even before it starts. But with several screening options available, how do you know which one is right for you? Here’s a breakdown of the most common colorectal cancer screening methods, their pros and cons, and how they compare. This isn’t medical advice— just general information for your reading pleasure.

1. Colonoscopy

  • How it works: A doctor uses a long flexible camera to examine the entire colon and rectum. Polyps can be removed during the procedure.

  • Frequency: Every 10 years (if normal), every 3-5 years if abnormal (to be determined after you get your report back)

  • Pros:

    • Detects and removes precancerous polyps in one step (diagnostic and therapeutic)

    • Gold standard for accuracy

  • Cons:

    • Requires the dreaded bowel prep

    • Sedation (general anesthesia) needed. Some will do it while you’re awake and mildly drowsy but the chances of you moving during a colonoscopy far outweighs the benefits. Besides, what’s a little propofol nap gonna hurt?

    • Risk of bleeding or perforation- though the risk is small, it exists, because this is a medical procedure.

2. Fecal Immunochemical Test (FIT)

  • How it works: Detects hidden blood in stool, which can be a sign of cancer or large polyps.

  • Frequency: Annually

  • Pros:

    • Non-invasive, done at home

    • No dietary restrictions or bowel prep

  • Cons:

    • Can’t detect polyps directly

    • Positive results require a follow-up colonoscopy

    • You’re smearing poop onto a card.

3. Cologuard (Multitarget Stool DNA Test)

  • How it works: Combines FIT with DNA markers that may signal cancer or advanced polyps.

  • Frequency: Every 3 years

  • Pros:

    • Non-invasive, at-home test

    • More sensitive than FIT for cancer

  • Cons:

    • Higher false-positive rate

    • Positive result requires colonoscopy

    • Not recommended for high-risk individuals

    • You’re smearing poop onto a card.

4. Flexible Sigmoidoscopy

  • How it works: Examines the lower third of the colon with a shorter, flexible scope.

  • Frequency: Every 5 years (or every 10 years with FIT)

  • Pros:

    • Less invasive than full colonoscopy

    • No sedation required

    • Can be beneficial in young people, who tend to have left-sided tumors

  • Cons:

    • Doesn’t examine the entire colon

    • Misses right-sided polyps

5. CT Colonography (Virtual Colonoscopy)

  • How it works: Uses a CT scan to re-create images of the colon, sometimes in 3D.

  • Frequency: Every 5 years

  • Pros:

    • Non-invasive

    • No sedation

  • Cons:

    • Requires bowel prep

    • Cannot remove polyps—follow-up colonoscopy needed for anything suspicious

    • May detect unrelated findings (“incidentalomas” that we would not have known about otherwise)

Choosing the Right Test

Your choice depends on your age, risk factors, personal preferences, and access to care. This should be a thoughtful discussion had with your healthcare provider.

  • Average-risk adults should begin screening at age 45.

  • Those with family history or genetic syndromes may need earlier and more frequent screening.

Bottom Line:

No matter which test you choose, the best colorectal cancer screening method is the one you actually do. Talk to your doctor to find the right fit—and don’t wait. Early detection can save your life.

Screen smart. Live longer. Get screened.

DR. CARMEN FONG
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